Fundamentals of Investigations in Biotechnology

Major: Biomedical Engineering (Internet of Things)
Code of subject: 6.163.03.E.091
Credits: 5.00
Department: Electronics and Information Technology
Lecturer: Hlinenko Larysa
Semester: 6 семестр
Mode of study: денна
Learning outcomes: By the end of the study, learners are expected to: – know fundamentals of methodology of modelling the engineering systems as well as biological and bioengineering ones, apply the system approach to the bioengineering systems modelling ; – be able to create and investigate the mathematical models of the of the engineering and biological constituents of bioengineering systems considering their mutual impact; – be able to plan and realize computer experiments with models applying modern information technologies; – be able to apply the acquired modelling skills in the process of analysis and synthesis of the of bioengineering systems and their constituents; – be able to present modelling results and to substantiate the conclusions while discussing them with other students
Required prior and related subjects: – Biophysics – Informatics in biomedical engineering – Fundamentals of Biochemistry – Fundamentals of Biomedical Equipment Design
Summary of the subject: Concept and characteristics of systems. Biotechnical systems and their special features. Concept and main principles of system modelling. Mathematical modelling. Basic requirements to mathematical models and their characteristics. Model validation. Fundamentals of construction and identification of mathematical model objects and parameters on the basis of experimental dependences, basics of correlation analysis and regression analysis. Statistical modelling of biotechnical systems. Fundamentals of graph theory and graph presentation of mathematical models. Equivalent circuits of physical subsystems. Macrolevel modelling of physical subsystems of biotechnical systems engineering constituents on base of analogies with electric circuits. Mathematical models of engineering constituents at macrolevel: methods of construction. Fundamentals of theories of similarity and dimension. Modelling of biotechnical systems biological constituents. Principles of modelling the isolated physiological systems. Modelling of certain isolated physiological systems (modelling the circulatory system, cardiovascular system, respiratory system etc.). Interaction of organism physiological systems. Principles of modelling and models of bound physiological systems. Computer structure modelling of physiological systems. Interaction of engineering and biological constituents of bioengineering systems. Bioengineering systems simulation modelling, compartmental models. Computer-aided modelling of biotechnical systems constituents.
Assessment methods and criteria: – Current control: laboratory reports, individual exercises, oral interviewing, written and computer tests – 40 points (40 %): execution and defence of laboratory works and individual exercises - 10 points; tests - 30 points – Final control: control procedure - written and verbal examination (60 %): written examination (test) - 54 points; oral interviewing (verbal examination) - 6 points
Recommended books: 1. Гліненко Л.К. Основи біотехнічних систем та їх моделювання: навчальний посібник / Л.К.Гліненко, В.А.Павлиш, В.М.Фаст, Є.І.Яковенко. - Львів: Видавництво Львівської політехніки, 2020. – 380 c. 2. Павлиш В.А. Основи інформаційних технологій і систем: навч. посібник / В.А.Павлиш, Л.К. Гліненко. - Львів: Видавництво львівської політехніки, 2013. - 500 с. 3. Khoo M.C.K. Mathematical Modeling. In: Khoo M.C.K. Physiological Control Systems. AnaLysis, Simulation and Estimation. – John Wiley & Son, Inc., 2015. – 467 p. - P. 23-37. 4. Khoo M.C.K. Identification of Physiological ControlSystems. In: Khoo M.C.K. Physiological Control Systems. AnaLysis, Simulation and Estimation. – John Wiley & Son, Inc., 2015. – 467 p. - P. 159-202. 5. Enderle J. Compartmental Modeling / J.Enderle, J.Bronzino. In Enderle J. Introduction to Biomedical Engineering / J.Enderle, J.Bronzino. – Elsevier Inc., 2012. - P. 360 - 445. 6. Enderle J. Physiological Modeling / J.Enderle. In Enderle J. Introduction to Biomedical Engineering / J.Enderle, J.Bronzino. – Elsevier Inc., 2012. - P. 693 - 798.